The human body contains an endocannabinoid system made up of natural neurotransmitters called endocannabinoids and cannabinoid receptors, as well as cannabinoid receptor proteins. CBD works by binding to cannabinoid receptors, thereby affecting the receptor activity of the endocannabinoid system.
A well-studied aspect of pure cure oil is its ability to bind to the cannabinoid CB1 receptor in the central nervous system. This is the same receptor that THC binds to create highs. While THC activates CB1 signaling, CBD appears to attenuate it. This opposite mechanism is the reason why psychedelic effects are practically absent when using CBD. CBD also binds to other receptors, making it a potentially useful treatment for a range of brain-related diseases.
The side effects of CBD oil are minimal. The most common side effects of CBD oil include nausea, fatigue, and irritability. The bigger issue is that CBD can affect how the body processes certain over-the-counter medications, prescriptions, and dietary supplements. Because of this risk, clients should seek medical advice before starting to use CBD oils. A doctor should be consulted prior to use if they have a serious medical condition or are taking prescription medication.
CBD oils for epilepsy: FDA approved
While the use of CBD oil is common in a number of conditions, it has only been approved by the FDA to treat certain conditions of epilepsy. People have been using the cannabis plant to treat epilepsy since the nineteenth century. As a therapeutic agent, CBD oil has finally received drug approval. Epidiolex , the only CBD prescription approved by the FDA.
Epidiolex is used to treat seizures associated with Lennox-Gastaut syndrome (LGS) and Dravet syndrome. More than 500 patients took part in three rigorous clinical trials ahead of FDA approval, and most patients continued to take Epidiolex even after the trials were completed. The antiepileptic effect of CBD appears to be due to the binding of CBD to the GPR55 protein, which can induce seizures under normal conditions.
CBD oil has been tested on cells and in preclinical trials as a treatment for a range of conditions besides epilepsy. The most promising laboratory test results are associated with psychosis, anxiety and pain. While research is ongoing, no other CBD drug has yet been tested as thoroughly as Epidiolex.
CBD oils for psychosis, anxiety and pain
Small-scale clinical trials show that CBD may be effective in the treatment of psychosis, in particular schizophrenia. In 2012, a team of scientists compared the use of CBD as a treatment with standard treatment with amisulpride. In most cases, CBD has worked as well or better than amisulpride in fighting the symptoms of schizophrenia. CBD may be linked to increased levels of anandamide, a cannabinoid produced by the body that may provide protection against psychosis.
In anxious people, serotonin levels in the brain can be below normal, which can be the cause of depression in many people. CBD Oil for Anxiety Reduction is based on boosting low serotonin levels. Most of the general research on anxiety has been limited to animal models and more research in humans is needed. However, certain forms of anxiety seem to respond well to CBD oil and other CBD products. Individuals suffering from Post Traumatic Stress Disorder (PTSD) have found relief of symptoms such as nightmares and memory recall when taking CBD oil.
CBD oil for pain is becoming more and more popular among people with chronic pain. CBD is thought to reduce pain, inflammation, and general discomfort. It is an attractive alternative to opioids, which can be addictive and cause shorter and longer term side effects. The binding of CBD to various endocannabinoid receptors contributes to the anti-inflammatory and pain-relieving effects of CBD oil.
While there has been some degree of research done for pain associated with diseases ranging from cancer, migraine and arthritis, more human studies are needed to confirm how and to what extent CBD oil can be used to relieve pain. The bottom line is that while there are many experimental and anecdotal promises about CBD’s role in pain management for the body and mind, more evidence is needed before more CBD products are approved as therapeutic agents.
Influence of genetics
Many of the conditions treated with CBD oils are genetic. By understanding the genetics of things like susceptibility to pain and anxiety, clients can make more informed decisions when choosing supplements containing CBD.
Because anxiety and depression are associated with low serotonin levels, they are often treated with selective serotonin reuptake inhibitors (SSRIs), with CBD oil becoming a popular alternative. A growing body of research is showing that neurological disorders such as anxiety and depression have a genetic basis. With the Nebula Research Library, clients have access to the very latest research.
For example, a 2019 genome-wide association study identified a number of genetic variants associated with various anxiety or stress disorders. The cohort included 12,000 people diagnosed with this disorder and more than 19,000 people from the control group. Another genome-wide association study in 2018 dealt with major depressive disorder (MDD). This study found a link between more than 400,000 people of European descent and several genetic variants expressed in areas of the brain known to play a role in depression.
Chronic pain is another area where people claim to see the benefits of CBD oil. Pain caused by medical disorders can be strongly influenced by genes. Potential customers of CBD oil may want to understand their risks of inflammation-related diseases such as arthritis.